PEX Packaging With Local Packages See setup.py in the repository root. This is required for PEX when running pex . to include local packages. See pex commandin Makefile. Based on these Stack Overflow answers: https://stackoverflow.com/a/49565672/9285942 https://stackoverflow.com/a/47491776/9285942 Install Pex pip3 install -r requirements.dev.txt Build make build Run make run