diff --git a/src/scripts/browserDeviceProfile.js b/src/scripts/browserDeviceProfile.js
index 755e6e70e75..8c6cd686d3f 100644
--- a/src/scripts/browserDeviceProfile.js
+++ b/src/scripts/browserDeviceProfile.js
@@ -1028,6 +1028,48 @@ export default function (options) {
         profile.TranscodingProfiles.push(...flacTranscodingProfiles);
     }
 
+    if (safariSupportsOpus) {
+        const opusConditions = [
+            // Safari doesn't support opus with more than 2 channels
+            {
+                Condition: 'LessThanEqual',
+                Property: 'AudioChannels',
+                Value: '2',
+                IsRequired: false
+            }
+        ];
+
+        profile.CodecProfiles.push({
+            Type: 'VideoAudio',
+            Codec: 'opus',
+            Conditions: opusConditions
+        });
+
+        const opusTranscodingProfiles = [];
+
+        // Split each video transcoding profile with opus so that the containing opus is only applied to 2 channels audio
+        profile.TranscodingProfiles.forEach(transcodingProfile => {
+            if (transcodingProfile.Type !== 'Video') return;
+
+            const audioCodecs = transcodingProfile.AudioCodec.split(',');
+
+            if (!audioCodecs.includes('opus')) return;
+
+            const opusTranscodingProfile = { ...transcodingProfile };
+            opusTranscodingProfile.AudioCodec = 'opus';
+            opusTranscodingProfile.ApplyConditions = [
+                ...opusTranscodingProfile.ApplyConditions || [],
+                ...opusConditions
+            ];
+
+            opusTranscodingProfiles.push(opusTranscodingProfile);
+
+            transcodingProfile.AudioCodec = audioCodecs.filter(codec => codec != 'opus').join(',');
+        });
+
+        profile.TranscodingProfiles.push(...opusTranscodingProfiles);
+    }
+
     let maxH264Level = 42;
     let h264Profiles = 'high|main|baseline|constrained baseline';